Customized Adjuvant Chemotherapy: Prognostic and Predictive Factors
نویسندگان
چکیده
منابع مشابه
Prognostic & predictive factors for planning adjuvant chemotherapy of early-stage breast cancer
Breast cancer is a heterogeneous disease and may present with different clinical and biological characteristics. At present, breast cancer is divided into molecular subgroups besides its histopathological classification. Decision for adjuvant chemotherapy is made based on not only histopathological characteristics but also molecular and genomic characteristics using indices, guidelines and calc...
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Colorectal cancer (CRC) is a highly heterogeneous disease regarding the stage at time of diagnosis and there is special attention regarding adjuvant chemotherapy in unselected patients with stage I and stage II. The clinicohistologically based TNM staging system with emphasis on histological evaluation of primary tumor and resected regional lymph nodes remains the standard of staging, but it ha...
متن کاملPrognostic and predictive factors.
Prognostic factors are key elements for medical oncologists to select, among the group of patients with early breast cancer, those who are candidates for an adjuvant treatment based on their risk of tumor relapse. Predictive factors drive the decision of which type(s) of treatment should be given. If we perform a literature search on prognostic and predictive factors in breast cancer we immedia...
متن کاملPrognostic and predictive gene signature for adjuvant chemotherapy in resected non-small-cell lung cancer.
PURPOSE The JBR.10 trial demonstrated benefit from adjuvant cisplatin/vinorelbine (ACT) in early-stage non-small-cell lung cancer (NSCLC). We hypothesized that expression profiling may identify stage-independent subgroups who might benefit from ACT. PATIENTS AND METHODS Gene expression profiling was conducted on mRNA from 133 frozen JBR.10 tumor samples (62 observation [OBS], 71 ACT). The min...
متن کاملPrognostic factors of locally advanced breast cancer patients receiving neoadjuvant and adjuvant chemotherapy.
BACKGROUND Neoadjuvant chemotherapy is known to be beneficial for down-staging patients with locally advanced breast cancer. Clinical stage, degree of cell differentiation and expression of estrogen/progesterone receptors and HER2/neu are all prognostic factors that may effect survival of patients with locally advanced breast cancer. The present study was conducted to determine their influence ...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2012
ISSN: 0923-7534
DOI: 10.1093/annonc/mds385